The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature.

@article{Lodge2009TheHO,
  title={The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature.},
  author={David Lodge},
  journal={Neuropharmacology},
  year={2009},
  volume={56 1},
  pages={6-21}
}
In this article, the beginnings of glutamate pharmacology are traced from the early doubts about 'non-specific' excitatory effects, through glutamate- and aspartate-preferring receptors, to NMDA, quisqualate/AMPA and kainate subtypes, and finally to the cloning of genes for these receptor subunits. The development of selective antagonists, crucial to the subtype classification, allowed the fundamental importance of glutamate receptors to synaptic activity throughout the CNS to be realised. The… CONTINUE READING