The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents

@article{Scher2013TheHO,
  title={The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents},
  author={Bernard S{\'e}cher and Rosa Fregel and Jos{\'e} Mar{\'i}a Larruga and Vicente M. Cabrera and Phillip Endicott and Jos{\'e} J. Pestano and Ana Mar{\'i}a Gonz{\'a}lez},
  journal={BMC Evolutionary Biology},
  year={2013},
  volume={14},
  pages={109 - 109}
}
BackgroundComplete mitochondrial DNA (mtDNA) genome analyses have greatly improved the phylogeny and phylogeography of human mtDNA. Human mitochondrial DNA haplogroup U6 has been considered as a molecular signal of a Paleolithic return to North Africa of modern humans from southwestern Asia.ResultsUsing 230 complete sequences we have refined the U6 phylogeny, and improved the phylogeographic information by the analysis of 761 partial sequences. This approach provides chronological limits for… 

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References

SHOWING 1-10 OF 82 REFERENCES
Mitochondrial DNA transit between West Asia and North Africa inferred from U6 phylogeography
TLDR
The most probable origin of the proto-U6 lineage was the Near East, and around 30,000 years ago it spread to North Africa where it represents a signature of regional continuity.
Major genomic mitochondrial lineages delineate early human expansions
TLDR
The relative relationships among the 42 human lineages are shown and more accurate temporal calibrations are presented than have been previously possible to give new perspectives as how modern humans spread in the Old World.
Population expansion in the North African Late Pleistocene signalled by mitochondrial DNA haplogroup U6
TLDR
Improved resolution of the mitochondrial DNA (mtDNA) haplogroup U6 phylogeny has enabled us to infer a signal of moderate population expansion using Bayesian coalescent methods, pointing to a moderate impact of the late Neolithic on the local population size of the southern Mediterranean coast.
Mitochondrial lineage M1 traces an early human backflow to Africa
TLDR
This study provides evidence that M1, or its ancestor, had an Asiatic origin, and a relevant fraction of M1a lineages present today in the European Continent and nearby islands possibly had a Jewish instead of the commonly proposed Arab/Berber maternal ascendance.
A signal, from human mtDNA, of postglacial recolonization in Europe.
TLDR
The present study shows that the dissection of mtDNA variation into small and well-defined evolutionary units is an essential step in the identification of spatial frequency patterns, and promises to be an efficient strategy for inferring features of human prehistory.
Human Y chromosome haplogroup R-V88: a paternal genetic record of early mid Holocene trans-Saharan connections and the spread of Chadic languages
TLDR
It is suggested that R-V88 is a paternal genetic record of the proposed mid-Holocene migration of proto-Chadic Afroasiatic speakers through the Central Sahara into the Lake Chad Basin, and geomorphological evidence is consistent with this view.
Mitochondrial DNA affinities at the Atlantic fringe of Europe.
TLDR
Mitochondrial DNA analysis of Atlantic European samples has detected significant latitudinal clines for several clusters with Paleolithic and Neolithic coalescence ages in Europe, and it is proposed that a pre-Neolithic origin for this gene flow is proposed.
The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations
TLDR
A set of unique event polymorphisms associated with the non‐recombining portion of the Y‐chromosome (NRY) addresses this issue by providing evidence concerning successful migrations originating from Africa, which can be interpreted as subsequent colonizations, differentiations and migrations overlaid upon previous population ranges.
Mitochondrial Haplogroup H1 in North Africa: An Early Holocene Arrival from Iberia
TLDR
The scenario of an arrival of haplogroup H1 in North Africa from Iberia at the beginning of the Holocene is supported, as a consequence of the improvement in climate conditions after the Younger Dryas cold snap, followed by in situ formation of local H1 sub-haplogroups.
Divorcing the Late Upper Palaeolithic demographic histories of mtDNA haplogroups M1 and U6 in Africa
TLDR
High-resolution phylogenetic dissection of both haplogroups and coalescent time assessments suggest that the extant main branching pattern of both Haplogroups arose and diversified in the mid-later Upper Palaeolithic, with some sub-clades concomitantly with the expansion of the Iberomaurusian industry.
...
1
2
3
4
5
...