The history of folic acid

@article{Hoffbrand2001TheHO,
  title={The history of folic acid},
  author={A. Victor Hoffbrand and D. G. Weir},
  journal={British Journal of Haematology},
  year={2001},
  volume={113}
}
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Folic acid Deficiency and risk of Prematurity
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The aim of this study was to determine the third trimester status of men in Iraq as well as identify a group of men suitable for delivery as a pre-term delivery group.
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TLDR
Translational application of these findings could result in a breakthrough in the primary prevention of NTD, but so far this is not widely applied in practice.
Folate Deficiency and Folic Acid Supplementation: The Prevention of Neural-Tube Defects and Congenital Heart Defects
TLDR
The findings of the Hungarian intervention trials indicated that periconceptional folic acid (FA)-containing multivitamin supplementation prevented the major proportion of neural-tube defects (NTD) as well as a certain proportion of congenital heart defects.
Methods for assessment of folate (Vitamin B9)
How Is the Oxidation Related to the Tautomerization in Vitamin B9?
The relationship between the lactim-lactam tautomerization and the free-radical scavenging reaction in vitamin B9 [folic acid (FA)] was investigated by density functional theory calculations.
Folic Acid/Folic Acid-Containing Multivitamins and Primary Prevention of Birth Defects and Preterm Birth
TLDR
The deficiency or overdosage of certain nutrients may have a role in the origin of birth defects and teratogenic effect of 4-aminopteroylglutamic acid (aminopterin), a folic acid antagonist, was confirmed in man as well as in man recently.
Novel Spectroscopic Methods for Determination of Folic Acid in Pharmaceutical Formulations
TLDR
These methods, which are based on the formation of colored species on binding of Folic acid with Sodium nitroprusside and Ammonia reagent to produce a dark yellow colored chromogen, could be treated as simple, sensitive and reproduciblebased on the principle of absorption visible spectrophotmetry for the determination ofFolic acid in pharmaceutical formulations.
Periconceptional Folic Acid Supplementation: A New Indication for Therapeutic Drug Monitoring
TLDR
Therapeutic drug monitoring (TDM) of RBC folate could be used to identify women and to help them improve their folate status, thus reducing their risk for having a child with an NTD.
Micronutrient Intake During Pregnancy: Effects of Excessive Folic Acid on Placental Health and Function
TLDR
This book aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
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The effect of vitamin B12 deficiency on methylfolate metabolism and pteroylpolyglutamate synthesis in human cells.
TLDR
It is suggested that reduced synthesis of pteroylpolyglutamates reported by others in vitamin B 12 -deficient cells may be secondary to the failure of removal of the methyl group from methyltetrahydrofolate rather than to a direct effect of vitamin B B 12 deficiency on the enzyme responsible for pteroyslpoly glutamate synthesis.
Interrelations of vitamin B12 and folic acid metabolism: folic acid clearance studies.
TLDR
Preliminary results of part of these studies suggest that folic acid activity "piles up" in human serum in the presence of vitamin B12 deficiency, and provides direct evidence of deranged folic Acid metabolism due to vitamin B 12 deficiency.
Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects.
TLDR
Plasma folate and plasma B12 were independent risk factors for NTDs, suggesting that the enzyme methionine synthase is involved directly or indirectly in the aetiology.
The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother.
TLDR
A biological model of MTHFR-related NTD pathogenesis is favored, in which suboptimal maternal folate status imposes biochemical stress on the developing embryo, a stress it is ill-equipped to tolerate if it has a TT genotype.
A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects.
TLDR
Genetic screening could identify women who will require folic acid supplements to reduce their risk of having a child with an NTD, and explains the association between some NTDs and elevated homocysteine, given that the reductase is important in homocy steine metabolism.
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TLDR
Folic acid administered to a patient with macrocytic anemia due to faulty postoperative intestinal digestion and absorption, produced a complete remission in the blood picture and a marked improvement in signs and symptoms.
Folic acid--an innocuous means to reduce plasma homocysteine.
TLDR
It is proposed that folic acid in excess acts by enhancing the remethylation of homocysteine to methionine, which confirms a previous report and might be of use as prophylaxis.
Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.
TLDR
A randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects.
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THE PRODUCTION OF FOLIC ACID BY RAT LIVER IN VITRO
TLDR
The data presented favor the last hypothesis and suggest that xanthopterin, or a substance derived from it, may constitute a portion of the folic acid molecule.
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