The history of Toll-like receptors — redefining innate immunity
@article{ONeill2013TheHO, title={The history of Toll-like receptors — redefining innate immunity}, author={Luke A. J. O’Neill and Douglas T. Golenbock and Andrew G. Bowie}, journal={Nature Reviews Immunology}, year={2013}, volume={13}, pages={453-460} }
The discovery of Toll-like receptors (TLRs) was an important event for immunology research and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or Medicine to Jules Hoffmann and Bruce Beutler, who, together with Ralph Steinman, the third winner of the 2011 Nobel Prize and the person who discovered the dendritic cell, were pioneers in the field of innate immunity. TLRs have a central role in immunity — in this Timeline article, we describe the landmark findings that…
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References
SHOWING 1-10 OF 126 REFERENCES
The roles of TLRs, RLRs and NLRs in pathogen recognition.
- BiologyInternational immunology
- 2009
Recent insights into pathogen sensing by PRRs are summarized and specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes are summarized.
TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein
- BiologyScience
- 2005
A profilin-like molecule from the protozoan parasite Toxoplasma gondii is identified that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88 and is the first chemically defined ligand for this TLR.
Control of B-cell responses by Toll-like receptors
- BiologyNature
- 2005
It is found that, in addition to CD4+ T-cell help, generation of T-dependent antigen-specific antibody responses requires activation of TLRs in B cells.
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
- BiologyNature Immunology
- 2000
A common receptor activation pathway can initiate innate immune responses to both bacterial and viral pathogens.
Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer
- BiologyPharmacological Reviews
- 2009
Recent advances in the understanding of signaling pathways activated by TLRs, structural insights into TLRs bound to their ligands and antagonists, and approaches to inhibit TLRs are providing possible means by which to interfere with TLRs clinically.
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2000
The data suggest that TLRs sample the contents of the phagosome independent of the nature of the contents, and can establish a combinatorial repertoire to discriminate among the large number of pathogen-associated molecular patterns found in nature.
Genetic variation in Toll-like receptors and disease susceptibility
- BiologyNature Immunology
- 2012
This work has demonstrated complex interaction between genetic variation in TLRs and environmental factors that explains the differences in the effect of TLR polymorphisms on susceptibility to infection and autoimmune disease in various populations.
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
- BiologyImmunity
- 2013
Structures of the toll-like receptor family and its ligand complexes.
- Biology, ChemistryImmunity
- 2008
Discrimination of bacterial lipoproteins by Toll-like receptor 6.
- BiologyInternational immunology
- 2001
Results show that TLR6 recognizes MALP-2 cooperatively with TLR2, and appears to discriminate between the N-terminal lipoylated structures of MALp-2 and lipopeptides derived from other bacteria.