The history and theory of the doubly labeled water technique.

@article{Speakman1998TheHA,
  title={The history and theory of the doubly labeled water technique.},
  author={John R. Speakman},
  journal={The American journal of clinical nutrition},
  year={1998},
  volume={68 4},
  pages={
          932S-938S
        }
}
  • J. Speakman
  • Published 1 October 1998
  • Biology
  • The American journal of clinical nutrition
Scientists have been measuring energy expenditure by using gas exchange for the past 200 y. This technique is based on earlier work in the 1660s. Gas exchange in respirometers provides accurate and repeatable measures of resting metabolic rate. However, it is impossible to duplicate in a respirometry chamber the diversity of human behaviors that influence energy expenditure. The doubly labeled water technique is an isotope-based method that measures the energy expenditure of unencumbered… 

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References

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The doubly labeled water method is a form of indirect calorimetry that has been developed only recently and has a precision of 2-8% depending on the isotope dose and the length of the elimination period.

Principles, problems and a paradox with the measurement of energy expenditure of free-living subjects using doubly-labelled water.

  • J. Speakman
  • Environmental Science
    Statistics in medicine
  • 1990
Improvements in understanding of the doubly-labelled water technique, in the methods for calculating carbon dioxide production and in the accuracy of mass spectrometry, have not led to improvements in the accuracies of the technique.

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