third generation dermal fillers at the facial aeshetic dental interface, let us look back at the early dermal fillers, as well as examining some of the key brand names available on the market today. We will look at their individual derivation (bovine/human), their gel particle size, degree of crosslinking and percentage of crosslinking within that degree of cross-linking. However, let us first look back a little at the early dermal fillers, their FDA approval, and indeed the relevance of FDA approval or non-approval, as well as off-label use (including any legal ramifications of off-label use) before critically analysing the use of dermal fillers within any aesthetic practice. Bovine-derived collagen Zyplast 1 was the first FDAapproved dermal filler; this was nearly 30 years ago, back in 1981. Zyderm 1 had the potential to cause an allergic reaction as a result of its bovine collagen, plus its effects didn’t last very long (less than two months) and it gave disappointing results for deep folds and scars. As a result, two years later Zyderm 2 and Zyplast were FDA-approved and introduced into the market. Zyplast gave significantly improved results for deeper folds. These dermal fillers were then the sole FDA-approved fillers for over a decade (Murray, 2005).