The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1.

@article{Hussey2014TheHV,
  title={The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1.},
  author={Kristine M. Hussey and Hongshan Chen and Christine C Yang and Eugene Park and Nasun Hah and Hediye Erdjument-Bromage and Paul Tempst and Matthew J. Gamble and W Lee Kraus},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 13},
  pages={2437-49}
}
MacroH2A1 is a histone variant harboring an ∼25-kDa carboxyl-terminal macrodomain. Due to its enrichment on the inactive X chromosome, macroH2A1 was thought to play a role in transcriptional repression. However, recent studies have shown that macroH2A1 occupies autosomal chromatin and regulates genes in a context-specific manner. The macrodomain may play a role in the modulation of gene expression outcomes via physical interactions with effector proteins, which may depend on the ability of the… CONTINUE READING