The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes.

@article{Collins2015TheHM,
  title={The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes.},
  author={Patrick L. Collins and Katherine E. Kyle and Takeshi Egawa and Yoichi Shinkai and Eugene M. Oltz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 27},
  pages={8367-72}
}
Genome stability relies on epigenetic mechanisms that enforce repression of endogenous retroviruses (ERVs). Current evidence suggests that distinct chromatin-based mechanisms repress ERVs in cells of embryonic origin (histone methylation dominant) vs. more differentiated cells (DNA methylation dominant). However, the latter aspect of this model has not been tested. Remarkably, and in contrast to the prevailing model, we find that repressive histone methylation catalyzed by the enzyme SETDB1 is… CONTINUE READING
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