The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.

@article{Ladopoulos2013TheHM,
  title={The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.},
  author={Vasileios Ladopoulos and Helmut Hofemeister and Maarten Hoogenkamp and Arthur D. Riggs and Adrian Francis Stewart and Constanze Bonifer},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 7},
  pages={
          1383-93
        }
}
KMT2B (MLL2/WBP7) is a member of the MLL subfamily of H3K4-specific histone lysine methyltransferases (KMT2) and is vital for normal embryonic development in the mouse. To gain insight into the molecular mechanism underlying KMT2B function, we focused on MagohB, which is controlled by a CpG island promoter. We show that in cells lacking Mll2-the gene encoding KMT2B-the MagohB promoter resides in inaccessible chromatin and is methylated. To dissect the molecular events leading to the… CONTINUE READING
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