The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

@article{OrtegaMolina2015TheHL,
  title={The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development},
  author={Ana Ortega-Molina and Isaac W. Boss and Andr{\'e}s Canela and Heng Pan and Yanwen Jiang and Chunying Zhao and Man Jiang and Deqing Hu and Xabier Agirre and Itamar Niesvizky and Ji-Eun Lee and Hua-Tang Chen and Daisuke Ennishi and David W Scott and Anja Mottok and Christoffer Hother and Shichong Liu and Xing-Jun Cao and Wayne Tam and Rita Shaknovich and Benjamin A Garcia and Randy D. Gascoyne and Kai Ge and Ali Shilatifard and Olivier Elemento and Andr{\'e} Nussenzweig and Ari Melnick and Hans-Guido Wendel},
  journal={Nature Medicine},
  year={2015},
  volume={21},
  pages={1199-1208}
}
The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell lymphoma; however, the biological consequences of KMT2D mutations on lymphoma development are not known. Here we show that KMT2D functions as a bona fide tumor suppressor and that its genetic ablation in B cells promotes lymphoma development in mice. KMT2D deficiency also delays germinal center involution and impedes B cell… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 17 times over the past 90 days. VIEW TWEETS
41 Citations
47 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome

  • Bjornsson, H.T
  • Sci. Transl. Med. 6,
  • 2014

Similar Papers

Loading similar papers…