The histone-like protein Hlp is essential for growth of Streptococcus pyogenes: comparison of genetic approaches to study essential genes.

@article{Bugrysheva2011TheHP,
  title={The histone-like protein Hlp is essential for growth of Streptococcus pyogenes: comparison of genetic approaches to study essential genes.},
  author={Julia V. Bugrysheva and Barbara J. Froehlich and Jeffrey A Freiberg and June R. Scott},
  journal={Applied and environmental microbiology},
  year={2011},
  volume={77 13},
  pages={
          4422-8
        }
}
Selection of possible targets for vaccine and drug development requires an understanding of the physiology of bacterial pathogens, for which the ability to manipulate expression of essential genes is critical. For Streptococcus pyogenes (the group A streptococcus [GAS]), an important human pathogen, the lack of genetic tools for such studies has seriously hampered research. To address this problem, we characterized variants of the inducible Ptet cassette, in both sense and antisense contexts… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Synthetic riboswitches that induce gene expression in diverse bacterial species.

  • Applied and environmental microbiology
  • 2010
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Pathogenesis of group A streptococcal infections and their sequelae.

  • Advances in experimental medicine and biology
  • 2008
VIEW 2 EXCERPTS