The histone fold: a ubiquitous architectural motif utilized in DNA compaction and protein dimerization.

@article{Arents1995TheHF,
  title={The histone fold: a ubiquitous architectural motif utilized in DNA compaction and protein dimerization.},
  author={G Arents and Evangelos N. Moudrianakis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 24},
  pages={11170-4}
}
The histones of all eukaryotes show only a low degree of primary structure homology, but our earlier crystallographic results defined a three-dimensional structural motif, the histone fold, common to all core histones. We now examine the specific architectural patterns within the fold and analyze the nature of the amino acid residues within its functional segments. The histone fold emerges as a fundamental protein dimerization motif while the differentiations of the tips of the histone dimers… CONTINUE READING