The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells.

@article{Zeng2010TheHD,
  title={The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells.},
  author={Jiping Zeng and Zheng Ge and Lixiang Wang and Qiao Li and Na Wang and Magnus Bj{\"o}rkholm and Jihui Jia and Dawei Xu},
  journal={Gastroenterology},
  year={2010},
  volume={138 3},
  pages={
          981-92
        }
}
BACKGROUND & AIMS The aberrant expression of histone-modifying enzymes such as histone deacetylases contributes to oncogenesis. It is unclear whether RBP2, a newly identified histone demethylase, is involved in cancer development/progression. We determined RBP2 expression in gastric cancer and its biologic function in cancer cells. METHODS Cancerous and matched normal gastric specimens from 42 patients with gastric cancer were analyzed for RBP2 expression using quantitative real-time… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 70 CITATIONS, ESTIMATED 56% COVERAGE

Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis.

  • Cancer research
  • 2013
VIEW 7 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Histone demethylase retinoblastoma binding protein 2 regulates the expression of α-smooth muscle actin and vimentin in cirrhotic livers

  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Targeting the epigenome for treatment of cancer

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis

  • Molecular Cancer
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2011
2019

CITATION STATISTICS

  • 8 Highly Influenced Citations

  • Averaged 7 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 11 REFERENCES

VHL loss actuates a HIFindependent senescence programme mediated by Rb and p 400

AP Young, S Schlisio, YA Minamishima
  • Nat Cell Biol
  • 2008

Opposing effects of Ets and Id proteins on p 16 INK 4 a expression during cellular senescence

N Ohtani, Z Zebedee, TJ Huot
  • Nature
  • 2001

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1995

Similar Papers

Loading similar papers…