The histone demethylase PHF8 promotes adult acute lymphoblastic leukemia through interaction with the MEK/ERK signaling pathway.

@article{Fu2018TheHD,
  title={The histone demethylase PHF8 promotes adult acute lymphoblastic leukemia through interaction with the MEK/ERK signaling pathway.},
  author={Yue Fu and Yaling Yang and Xiaoming Wang and Xiaolin Yin and Minran Zhou and Siqi Wang and Lin Yang and Tao Huang and M Xu and Chun-yan Chen},
  journal={Biochemical and biophysical research communications},
  year={2018},
  volume={496 3},
  pages={981-987}
}
Adult acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid progenitor cells that is associated with a high risk of relapse and poor prognosis. Thus, novel pathogenic mechanisms and therapeutic targets need to be explored. Histone methylation is one of the most significant chromatin post-translational modifications. Here, we show that the… CONTINUE READING