The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.

  title={The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.},
  author={Barbara Banelli and Elisa Carra and Federica Barbieri and Roberto W{\"u}rth and Federica Parodi and Alessandra Pattarozzi and Roberta Carosio and Alessandra Forlani and Giorgio Allemanni and Daniela Marubbi and Tullio Florio and Antonio Daga and Massimo Romani},
  journal={Cell cycle},
  volume={14 21},
Notwithstanding current multimodal treatment, including surgery, radiotherapy and chemotherapy with temozolomide (TMZ), median survival of glioblastoma (GBM) patients is about 14 months, due to the rapid emergence of cell clones resistant to treatment. Therefore, understanding the mechanisms underlying chemoresistance is mandatory to improve treatments' outcome. We generated TMZ resistant cells (TMZ-R) from a GBM cell line and from cancer stem cell-enriched cultures isolated from human GBMs. We… CONTINUE READING
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