The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway

@inproceedings{Dong2019TheHD,
  title={The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway},
  author={Fangyuan Dong and Shuheng Jiang and Jun Li and Yahui Wang and Lili Zhu and Yiqin Huang and Xin Jiang and Xiaona Hu and Qi Zhou and Zhongye Zhang and Zhi-jun Bao},
  booktitle={EBioMedicine},
  year={2019}
}
BACKGROUND Accumulating evidence has revealed the pivotal role of epigenetic regulation in the pathogenesis of liver disease. However, the epigenetic mechanism that accounts for hepatic stellate cells (HSCs) activation in liver fibrosis remains largely unknown. METHODS Primary HSCs were used to screen the differentially expressed histone H3 lysine methyltransferases and demethylases during HSC activation. Loss-of-function experiments were applied to determine the cellular functions of KDM4D… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Liver inflammation and fibrosis.

  • The Journal of clinical investigation
  • 2017

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2014
VIEW 1 EXCERPT