The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro

@article{Sonnemann2010TheHD,
  title={The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro},
  author={J{\"u}rgen Sonnemann and Stephanie Gre\ssmann and Sabine Becker and Susan Wittig and Mareike Schmudde and James F. Beck},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2010},
  volume={66},
  pages={611-616}
}
It has recently been recognised that anticancer chemotherapy can elicit an immunogenic form of apoptosis characterised by the exposure of calreticulin (CRT) on the surface of dying tumour cells, entailing an immune response that contributes to the therapeutic outcome. CRT exposure has been found to be induced by anthracyclins and oxaliplatin, but not by other proapoptotic antineoplastic agents including etoposide, camptothecin and cisplatin. In this study, we examined the histone deacetylase… CONTINUE READING