The histone deacetylase inhibitor trichostatin a promotes apoptosis and antitumor immunity in glioblastoma cells.

@article{Hring2013TheHD,
  title={The histone deacetylase inhibitor trichostatin a promotes apoptosis and antitumor immunity in glioblastoma cells.},
  author={Elisabeth H{\"o}ring and Oliver Podlech and Bjoern Silkenstedt and Ioanna Alexandros Rota and Eleni Adamopoulou and Ulrike Naumann},
  journal={Anticancer research},
  year={2013},
  volume={33 4},
  pages={1351-60}
}
Histone deacetylase inhibitors (HDACi) have been described as multifunctional anticancer agents. The failure of conventional therapy for glioblastoma (GBM) renders this tumor an attractive target for immunotherapy. Innate immune cells, such as natural killer (NK) cells, play a crucial role in antitumor immune responses. Here, we describe how the HDACi trichostatin A (TSA) promotes apoptosis of tumor cells, as well as augments anti-GBM innate immune responses. In vitro treatment of GBM cells… CONTINUE READING

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