The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells.

@article{Hou2002TheHD,
  title={The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells.},
  author={Mi Hou and Xiongbiao Wang and Nikita Popov and Anju Zhang and Xiaoyan Zhao and Rong Zhou and Anders Zetterberg and Magnus Bj{\"o}rkholm and Marie Engstr{\"o}m Henriksson and Astrid Gruber and Dawei Xu},
  journal={Experimental cell research},
  year={2002},
  volume={274 1},
  pages={25-34}
}
Activation of telomerase, essential for cellular immortalization and transformation, requires the induction of its catalytic component, telomerase reverse transcriptase (hTERT). However, biochemical and genetic mechanisms for the control of hTERT expression remain undefined. In the present study, we demonstrate that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) induces hyperacetylation of histones at the hTERT proximal promoter, directly transactivates the hTERT gene in normal… CONTINUE READING

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