The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice.

@article{Reilly2008TheHD,
  title={The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice.},
  author={Christopher M. Reilly and Megan Thomas and Robert M. Gogal and S. Olgun and A. Del Santo and Renna Sodhi and Eileen Teresa Samy and Stanford L. Peng and Gary S. Gilkeson and Nilamadhab Mishra},
  journal={Journal of autoimmunity},
  year={2008},
  volume={31 2},
  pages={123-30}
}
We sought to determine if the histone deacetylase inhibitor (HDI), trichostatin A (TSA), would alter systemic lupus erythematosus (SLE) in NZB/W mice. Fourteen to sixteen-week-old female NZB/W F1 mice were given TSA (1.0mg/kg body weight (BW)) intraperitonealy (i.p.) daily, TSA (1.0mg/kg BW) i.p.+anti-CD25 (250mg/mouse) i.p. every third day, only anti-CD25 (250mg/mouse) i.p., DMSO or isotype IgG. Disease progression was assessed as they aged. Mice were sacrificed at 26 or 38 weeks of age… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Effects of histone deacetylase inhibitors on rat mesangial cells.

American journal of physiology. Renal physiology • 2010
View 7 Excerpts
Highly Influenced

Epigenetics in SLE

Current rheumatology reports • 2017

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Anti-CD25mAb, anti-IL2 mAb, and IL2block tolerance induction through anti-CD154mAband rapamycin in xenogeneic islet transplantation

PanH, HM Lu, +3 authors ZD Zhang
Transplant Proc 2007;39:3452–4 • 2007
View 1 Excerpt

HDAC inhibitors as anti-inflammatory agents.

British journal of pharmacology • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…