The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals

@article{SimonOBrien2015TheHD,
  title={The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals},
  author={Emmanuelle Simon-O'Brien and St{\'e}phanie Alaux-Cantin and Vincent Warnault and Romain Buttolo and Micka{\"e}l Naassila and Catherine Vilpoux},
  journal={Addiction Biology},
  year={2015},
  volume={20}
}
Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin remodeling may represent interesting targets in addiction treatment. No study has addressed whether histone deacetylase (HDAC) inhibitors (HDACi) can reduce excessive ethanol intake or prevent relapse in alcohol‐dependent animals. Here, we assessed the effects of two HDACi, sodium butyrate (NaB) and MS‐275, in the operant ethanol self‐administration paradigm in… 
The Class I-Specific HDAC Inhibitor MS-275 Decreases Motivation to Consume Alcohol and Relapse in Heavy Drinking Rats
TLDR
This study confirms the potential therapeutic interest of targeting epigenetic mechanisms in excessive alcohol drinking and strengthens the interest of focusing on specific isoforms of histone deacetylases.
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How chronic ethanol exposure regulates the highly prominent GABAAR α1 subunit by an epigenetic mechanism that represents a potential treatment modality for alcohol dependence is shown.
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While TsA-induced HDAC inhibition may be less protective against general amphetamine self-administration, it may decrease drug-seeking tendencies during relapse that are induced by the reintroduction of contextual environmental cues heavily associated with drug reward.
Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons
TLDR
Overall the results indicate that ethanol deacetylates histones associated with the Gabra1 promoter through class I HDACs and that pharmacologic, genetic, or epigenetic intervention prevents decreases in α1 expression in cultured cortical neurons.
Sodium butyrate modulates a methamphetamine‐induced conditioned place preference
TLDR
The results suggested a specific effect of histone acetylation on modulating distinct phases of METH‐induced CPP and that treatment of NaB during the extinction phase not only produced beneficial effects on eliminating already established CPP but also blocked the reinstatement of M ETH‐ induced CPP.
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