The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals

@article{SimonOBrien2015TheHD,
  title={The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals},
  author={Emmanuelle Simon-O'Brien and S. Alaux-Cantin and V. Warnault and R. Buttolo and M. Naassila and C. Vilpoux},
  journal={Addiction Biology},
  year={2015},
  volume={20}
}
Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin remodeling may represent interesting targets in addiction treatment. No study has addressed whether histone deacetylase (HDAC) inhibitors (HDACi) can reduce excessive ethanol intake or prevent relapse in alcohol‐dependent animals. Here, we assessed the effects of two HDACi, sodium butyrate (NaB) and MS‐275, in the operant ethanol self‐administration paradigm in… Expand
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