The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.

@article{Maggio2004TheHD,
  title={The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.},
  author={Sonia C. Maggio and Roberto R. Rosato and Lora B. Kramer and Yun Dai and Mohamed Rahmani and David S. Paik and Ann C Czarnik and Shawn G. Payne and Sarah Spiegel and Steven Grant},
  journal={Cancer research},
  year={2004},
  volume={64 7},
  pages={2590-600}
}
Interactions between the novel benzamide histone deacetylase (HDAC) inhibitor MS-275 and fludarabine were examined in lymphoid and myeloid human leukemia cells in relation to mitochondrial injury, signal transduction events, and apoptosis. Prior exposure of Jurkat lymphoblastic leukemia cells to a marginally toxic concentration of MS-275 (e.g., 500 nM) for 24 h sharply increased mitochondrial injury, caspase activation, and apoptosis in response to a minimally toxic concentration of fludarabine… CONTINUE READING
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