The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells

@article{Lucas2004TheHD,
  title={The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells},
  author={David E. Lucas and Melanie E. Davis and Mark R. Parthun and Andrew P. Mone and Shinichi Kitada and Krista Cunningham and E L Flax and Joseph Wickham and John C. Reed and John C. Byrd and Michael R Grever},
  journal={Leukemia},
  year={2004},
  volume={18},
  pages={1207-1214}
}
MS-275 is a histone deacetylase (HDAC) inhibitor that has been reported to mediate its cytotoxic effect through generation of reactive oxygen species (ROS) in proliferating hematopoietic cell lines. We examined efficacy of MS-275 in nonproliferating chronic lymphocytic leukemia (CLL) cells from patients. In these cells, MS-275 demonstrated an in vitro LC50 that was one log lower than for normal mononuclear cells. Following MS-275 treatment, histones H3 and H4 showed increased acetylation and… CONTINUE READING

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