The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells.

@article{Goldsmith2003TheHD,
  title={The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells.},
  author={Merrill E. Goldsmith and Masaki Kitazono and Patrick T. Fok and Takashi Aikou and Susan A. Bates and Tito Fojo},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 14},
  pages={
          5394-401
        }
}
PURPOSE Efficient adenovirus infection requires coxsackie-adenovirus receptor (CAR) and alpha(v) integrin. Whereas many malignant cells express these proteins poorly, normal tissues, especially liver, express high levels and are susceptible to adenovirus infection. Our previous studies showed that treatment of cancer cell lines with low concentrations of the histone deacetylase inhibitor FK228 (FR901228, depsipeptide), a drug in Phase II clinical trials, before infection was associated with an… CONTINUE READING

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Reactivation of silenced, virally transduced genes by 5400 FK228 Enhances Adenovirus Transgene

  • W. Y. Chen, E. C. Bailey, S. L. McCune, J. Y. Dong, T. M. Townes
  • Expression Research. on July
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