The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.

@article{Zhang2015TheHD,
  title={The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.},
  author={Jiao Zhang and X-J Yin and C Xu and Y-X Ning and M Chen and H Zhang and S R Chen and L Yao},
  journal={European review for medical and pharmacological sciences},
  year={2015},
  volume={19 5},
  pages={818-24}
}
OBJECTIVE SIRT6 belongs to the NAD+-dependent class III deacetylase sirtuin family. Accumulating evidences have supported the critical role of SIRT6 in the proliferation, differentiation, cell cycle progression and apoptosis of cancer cells. The present study aims to determine the expression of SIRT6 in human ovarian cancer tissues and further investigate its the biological effect in ovarian cancer. MATERIALS AND METHODS Real time PCR and western blot were performed to examine the mRNA and… CONTINUE READING
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