The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming.

@article{Cohen2007TheHD,
  title={The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming.},
  author={Todd J Cohen and David S. Waddell and Tomasa Barrientos and Zhonghua Lu and Guoping Feng and Gregory Allen Cox and Sue C. Bodine and Tso-pang Yao},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 46},
  pages={
          33752-9
        }
}
Neural activity actively regulates muscle gene expression. This regulation is crucial for specifying muscle functionality and synaptic protein expression. How neural activity is relayed into nuclei and connected to the muscle transcriptional machinery, however, is not known. Here we identify the histone deacetylase HDAC4 as the critical linker connecting neural activity to muscle transcription. We found that HDAC4 is normally concentrated at the neuromuscular junction (NMJ), where nerve… CONTINUE READING

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