The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

@article{Villagra2009TheHD,
  title={The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance},
  author={Alejandro V. Villagra and Fengdong Cheng and Hong-Wei Wang and Ildelfonso Suarez and Michelle Glozak and Michelle Maurin and Danny Nguyen and Kenneth L. Wright and Peter W Atadja and Kapil Bhalla and Javier Pinilla-Ibarz and Edward Seto and Eduardo M. Sotomayor},
  journal={Nature Immunology},
  year={2009},
  volume={10},
  pages={92-100}
}
Antigen-presenting cells (APCs) induce T cell activation as well as T cell tolerance. The molecular basis of the regulation of this critical 'decision' is not well understood. Here we show that HDAC11, a member of the HDAC histone deacetylase family with no prior defined physiological function, negatively regulated expression of the gene encoding interleukin 10 (IL-10) in APCs. Overexpression of HDAC11 inhibited IL-10 expression and induced inflammatory APCs that were able to prime naive T… CONTINUE READING

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