The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

  title={The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance},
  author={Alejandro V. Villagra and Fengdong Cheng and Hong-Wei Wang and Ildelfonso Suarez and Michelle Glozak and Michelle Maurin and Danny Nguyen and Kenneth L. Wright and Peter W Atadja and Kapil Bhalla and Javier Pinilla-Ibarz and Edward Seto and Eduardo M. Sotomayor},
  journal={Nature Immunology},
Antigen-presenting cells (APCs) induce T cell activation as well as T cell tolerance. The molecular basis of the regulation of this critical 'decision' is not well understood. Here we show that HDAC11, a member of the HDAC histone deacetylase family with no prior defined physiological function, negatively regulated expression of the gene encoding interleukin 10 (IL-10) in APCs. Overexpression of HDAC11 inhibited IL-10 expression and induced inflammatory APCs that were able to prime naive T… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 43 references

Regulatory T cell - derived interleukin - 10 limits inflammation at environmental interfaces

Y. P. Rubtsov
Immunity • 2008

Regulatory T cell-derived interleukin-10 limits inflammation

Rubtsov, Y.P
at environmental interfaces. Immunity • 2008

a duet by transforming growth factor-b and interleukin-10

M. O. Li, Flavell, R. A. Contextual regulation of inflammation
Immunity 28, 468–476 • 2008

from bacteria and yeast to mice and men

Yang, X.-J., Seto, E. The Rpd3Hda1 family of lysine deacetylases
Nat. Rev. Mol. Cell Biol. 9, 206–218 • 2008

Identification of a novel negative role of flagellin in regulating IL-10 production

I Vicente-Suarez
Eur. J. Immunol • 2007

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