The histone chaperone CAF-1 safeguards somatic cell identity

  title={The histone chaperone CAF-1 safeguards somatic cell identity},
  author={Sihem Cheloufi and Ulrich Elling and Barbara Hopfgartner and Youngsook L. Jung and Jernej Murn and Maria Ninova and Maria Hubmann and Aimee I. Badeaux and Cheen Euong Ang and Danielle E. Tenen and Daniel J Wesche and Nadezhda Abazova and Max Hogue and Nilgun Tasdemir and Justin Brumbaugh and Philipp Rathert and Julian Jude and Francesco Ferrari and Andres Blanco and Michaela Fellner and Daniel Wenzel and Marietta Zinner and Simon E. Vidal and Oliver Bell and Matthias Stadtfeld and Howard Y Chang and Genevi{\`e}ve Almouzni and Scott W Lowe and John L Rinn and Marius Wernig and A. A. Aravin and Yang Shi and Peter J. Park and Josef M. Penninger and Johannes Zuber and Konrad Hochedlinger},
Cellular differentiation involves profound remodelling of chromatic landscapes, yet the mechanisms by which somatic cell identity is subsequently maintained remain incompletely understood. To further elucidate regulatory pathways that safeguard the somatic state, we performed two comprehensive RNA interference (RNAi) screens targeting chromatin factors during transcription-factor-mediated reprogramming of mouse fibroblasts to induced pluripotent stem cells (iPS cells). Subunits of the chromatin… CONTINUE READING
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