The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3.

@article{Love2012TheHA,
  title={The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3.},
  author={Ian M. Love and Pedja Sekaric and Dingding Shi and Steven R. Grossman and Elliot J Androphy},
  journal={Cell cycle},
  year={2012},
  volume={11 13},
  pages={2458-66}
}
The activity of p53 as a tumor suppressor primarily depends on its ability to transactivate specific target genes in response to genotoxic and other potentially mutagenic stresses. Several histone acetyl transferases (HATs), including p300, CBP, PCAF and GCN5 have been implicated in the activation of p53-dependent transcription of the cyclin-dependent kinase (cdk) inhibitor p21 as well as other target genes. Here we show that PCAF, but not CBP or p300, is a critical regulator of p53-dependent… CONTINUE READING

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