The histone acetyltransferase MOF overexpression blunts cardiac hypertrophy by targeting ROS in mice.


Imbalance between histone acetylation/deacetylation critically participates in the expression of hypertrophic fetal genes and development of cardiac hypertrophy. While histone deacetylases play dual roles in hypertrophy, current evidence reveals that histone acetyltransferase such as p300 and PCAF act as pro-hypertrophic factors. However, it remains elusive… (More)
DOI: 10.1016/j.bbrc.2014.04.112


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