The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

@article{Tahiliani2007TheHH,
  title={The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation},
  author={Mamta Tahiliani and Pinchao Mei and Rui Fang and Thiago Leonor and Michael Scott Rutenberg and Fumiko Shimizu and Jing Li and Anjana Rao and Yujiang Geno Shi},
  journal={Nature},
  year={2007},
  volume={447},
  pages={601-605}
}
Gene transcription is critically influenced by chromatin structure and the modification status of histone tails. Methylation of lysine residues in histone tails is dynamically regulated by the opposing activities of histone methyltransferases and histone demethylases. Here we show that JARID1C/SMCX, a JmjC-domain-containing protein implicated in X-linked mental retardation and epilepsy, possesses H3K4 tri-demethylase activity and functions as a transcriptional repressor. An SMCX complex… CONTINUE READING
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