The histamine H4 receptor is functionally expressed on T(H)2 cells.

  title={The histamine H4 receptor is functionally expressed on T(H)2 cells.},
  author={Ralf Gutzmer and Susanne Mommert and Maria Gschwandtner and Katja Zwingmann and Holger Stark and Thomas T Werfel},
  journal={The Journal of allergy and clinical immunology},
  volume={123 3},
BACKGROUND Histamine influences T-cell reactions via histamine receptors 1 and 2. The histamine receptor 4 (H(4)R) is the most recently identified histamine receptor and is also expressed on human CD4(+) T cells; however, its regulation and function are unclear. OBJECTIVE To investigate expression, regulation, and function of the H(4)R on human CD4(+) T cells. METHODS Histamine receptor 4 expression was studied by real-time quantitative RT-PCR and by flow cytometry. Effects of H(4)R… CONTINUE READING
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The histamine H4 receptor antagonist JNJ 7777120 reduces hapten induced scratching behavior but not inflammation

  • K Rossbach, S Wendorff, H Stark, R Gutzmer, T Werfel, M Kietzmann
  • Exp Dermatol 2009;18:57-63
  • 2009

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