The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders.

@article{Passani2004TheHH,
  title={The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders.},
  author={Maria Beatrice Passani and J S Lin and Arthur Hancock and Sylvain Crochet and Patrizio Blandina},
  journal={Trends in pharmacological sciences},
  year={2004},
  volume={25 12},
  pages={618-25}
}
Histamine H3 receptor pharmacology, functions and biochemistry are far from being fully understood; however, progress is being made. Activation of this Gi/GO-protein-coupled receptor affects cognition, the sleep-wake cycle, obesity and epilepsy, which are physiological and pathological conditions that are the main focus of research into the therapeutic potential of selective H3 receptor ligands. This heterogeneity of targets can be reconciled partially by the fact that the histamine system… CONTINUE READING