The histamine H3 receptor: from gene cloning to H3 receptor drugs

@article{Leurs2005TheHH,
  title={The histamine H3 receptor: from gene cloning to H3 receptor drugs},
  author={R. Leurs and R. Bakker and H. Timmerman and I. D. Esch},
  journal={Nature Reviews Drug Discovery},
  year={2005},
  volume={4},
  pages={107-120}
}
Since the cloning of the histamine H3 receptor cDNA in 1999 by Lovenberg and co-workers, this histamine receptor has gained the interest of many pharmaceutical companies as a potential drug target for the treatment of various important disorders, including obesity, attention-deficit hyperactivity disorder, Alzheimer's disease, schizophrenia, as well as for myocardial ischaemia, migraine and inflammatory diseases. Here, we discuss relevant information on this target protein and describe the… Expand
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