The hippocampus and declarative memory: cognitive mechanisms and neural codes

  title={The hippocampus and declarative memory: cognitive mechanisms and neural codes},
  author={Howard Eichenbaum},
  journal={Behavioural Brain Research},
  • H. Eichenbaum
  • Published 14 December 2001
  • Biology, Psychology
  • Behavioural Brain Research
A general hippocampal computational model combining episodic and spatial memory in a spiking model
A novel computational model of the hippocampus (CA1, CA3 and dentate gyrus) is presented which creates a framework where spatial memory and episodic memory are explained together, and a detailed model is produced which is biologically realistic and capable of explaining how several computational components can work together to produce the emergent functional properties ofThe hippocampus.
Immediate Early Genes and the Mapping of Environmental Representations in Hippocampal Neural Networks
The hippocampus has received much attention by researchers interested in understanding the nature of “declarative” or “explicit” memory—the memory for discrete events, which requires conscious
Hippocampal Complex Contribution to Retention and Retrieval of Recent and Remote Episodic and Semantic Memories: Evidence from Behavioral and Neuroimaging Studies of Healthy and Brain-Damaged People
The evidence reviewed suggests strongly that the function of the hippocampus (and possibly of related limbic structures) is to help encode, retain, and retrieve experiences, no matter how long ago the events comprising the experience occurred.
Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory
The evidence suggests strongly that the function of the hippocampus (and possibly that of related limbic structures) is to help encode, retain, and retrieve experiences, no matter how long ago the events comprising the experience occurred, and no matter whether the memories are episodic or spatial.
Hippocampal-dependent spatial and episodic memory in humans.
The role of the human hippocampus in spatial and episodic memory was investigated using methods from neuropsychology, experimental psychology and functional magnetic resonance imaging, and the relationship between viewpoint independence, multi-modal context and semantic embedding in retrieval was discussed.
Time, Space and Hippocampal Functions
  • C. Hölscher
  • Biology, Psychology
    Reviews in the neurosciences
  • 2003
Evidence is presented from many different studies that the hippocampus is part of this system and plays a supportive role in associating complex multimodal information and laying down new memory traces and it is proposed that information processing and memory formation is shared by several brain areas that act as a functional system.
Functional MRI Studies on Human Declarative Memory
Declarative memory is defined as the conscious memory for facts and events. The medial temporal lobe (MTL) structures, i.e., the hippocampus with the adjacent parahippocampal region, are considered
Neural dynamics of the cognitive map in the hippocampus
Theoretical analysis is necessary to consider the biological neural dynamics for the sequence encoding of the memory of behavioral sequences, providing the cognitive map formation, and a series of theoretical models with the theta phase coding are reviewed.
Time (and space) in the hippocampus
  • H. Eichenbaum
  • Biology, Psychology
    Current Opinion in Behavioral Sciences
  • 2017


Episodic memory, semantic memory, and amnesia
This article reviews two kinds of relevant data: case studies where amnesia has occurred early in childhood, before much of an individual's semantic knowledge has been acquired, and experimental studies with amnesic patients of fact and event learning, remembering and knowing, and remote memory, finding no compelling support for the view that episodic and semantic memory are affected differently in medial temporal lobe/diencephalic amnesia.
Memory Systems 1994
Current thinking on memory systems of 1994, D.L. Schacter memory and working with memory - evaluation of a component process model and comparisons with other models, M.W. Tulving multiple memory systems - what and why - an update.
Place navigation impaired in rats with hippocampal lesions
It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
Experience-dependent, asymmetric expansion of hippocampal place fields.
Indirect evidence for Hebbian synaptic plasticity and a functional explanation for why place cells become directionally selective during route following are provided, namely, to preserve the synaptic asymmetry necessary to encode the sequence direction.
Spatial and behavioral correlates of hippocampal neuronal activity
While the complex stimuli that compose spatial cues are reflected in hippocampal neuronal activity, hippocampal processing is not limited to the representation of spatial location and the domain of hippocampal representation includes both spatial and nonspatial relations among multiple cues and the actions directed in relation to these cues, across cue modalities, and across behavioral paradigms.
Differential effects of early hippocampal pathology on episodic and semantic memory.
Global anterograde amnesia is described in three patients with brain injuries that occurred in one case at birth, in another by age 4, and in the third at age 9. Magnetic resonance techniques
Discordance of spatial representation in ensembles of hippocampal place cells
It is indicated that hippocampal neurons independently encode distinct subsets of the cues in a complex environment, although processing within the hippocampal network may actively reduce the simultaneous representation of conflicting orientation information.