The hippocampus and Pavlovian fear conditioning: Reply to Bast et al.
@article{Anagnostaras2002TheHA, title={The hippocampus and Pavlovian fear conditioning: Reply to Bast et al.}, author={Stephan G. Anagnostaras and Greg D. Gale and Michael S. Fanselow}, journal={Hippocampus}, year={2002}, volume={12} }
In a recent article that appeared in Hippocampus, we reviewed findings supporting a mnemonic role for the dorsal hippocampus (DH) in Pavlovian (contextual and tone) fear conditioning (Anagnostaras et al., 2001). We also detailed a view that has emerged over the years from this work that suggests that the hippocampus plays a highly selective role in the acquisition and temporary storage of contextual representations, as opposed to a role in conditional stimulus–unconditional stimulus (CS–US…
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A discrete lesion targeting area CA1, the sole output of the hippocampus to neocortex, was developed and tested the effects of this lesion on recent and remote memory in the watermaze task, in context fear conditioning, and in trace fear conditioning; in all three tasks, recent andRemote memory were similarly impaired after CA1 lesions.
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Examining the role of hippocampus in cocaine conditioned place preference (CPP) memory at different time points after conditioning found that excitotoxic hippocampal lesions impaired recent, but not remote cocaine CPP memory in mice, suggesting that contextual drug-associated memory reorganizes over time, and becomes independent of the hippocampus.
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Recently formed context fear memories can be retrieved without the hippocampus
- Biology, PsychologybioRxiv
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It is hypothesized that the retrieval deficit caused by ChR2 stimulation is due to an immediate reduction in hippocampal activity that does not provide enough time for other brain regions to compensate.
The ventral hippocampus supports a memory representation of context and contextual fear conditioning: implications for a unitary function of the hippocampus.
- Biology, PsychologyBehavioral neuroscience
- 2005
Data suggest that the memory for a novel context is distributed throughout the longitudinal extent of the hippocampus and that this representation helps to support contextual fear conditioning.
Amnesia for context fear is caused by widespread disruption of hippocampal activity
- Biology, PsychologyNeurobiology of Learning and Memory
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Dissociable effects of hippocampus lesions on expression of fear and trace fear conditioning memories in rats
- Biology, PsychologyHippocampus
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The current data suggest distinct roles in fear conditioning for three regions of the hippocampus: the septal zone is required for acquisition of trace fear conditioning, a larger portion ofThe hippocampus is critical for memory retrieval, and a region including the temporal zone is needed for expression of both trace and delay fear conditioning.
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Septal cholinergic neurons gate hippocampal output to entorhinal cortex via oriens lacunosum moleculare interneurons
- Biology, PsychologyProceedings of the National Academy of Sciences
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