The hinge deletion allelic variant of porcine IgA results from a mutation at the splice acceptor site in the first C alpha intron.

@article{Brown1995TheHD,
  title={The hinge deletion allelic variant of porcine IgA results from a mutation at the splice acceptor site in the first C alpha intron.},
  author={William R. A. Brown and Imre Kacskovics and Brad A Amendt and N B Blackmore and Max F. Rothschild and Rajesh D. Shinde and John E. Butler},
  journal={Journal of immunology},
  year={1995},
  volume={154 8},
  pages={3836-42}
}
Recently published genomic and cDNA sequences for porcine IgA suggested that the splice acceptor site in the C alpha 1-C alpha 2 intron was an AA rather than an AG dinucleotide. This possibility was tested in an in vitro HeLa cell splicing system using an RNA substrate corresponding to the genomic DNA with the putative AA splice site. Data indicated that splicing occurred at a cryptic AG site 12 nucleotides into the C alpha 2 domain rather than at the AA site. The possibility that swine B cells… CONTINUE READING
18 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…