The highly selective 5‐hydroxytryptamine (5‐HT)2A receptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test

@article{Patel2004TheHS,
  title={The highly selective 5‐hydroxytryptamine (5‐HT)2A receptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test},
  author={Jignesh G Patel and Gerd D. Bartoszyk and E Edwards and Charles R. Ashby},
  journal={Synapse},
  year={2004},
  volume={52}
}
We examined the effect of the highly selective 5‐hydroxytryptamine (5‐HT)2A receptor antagonist 7‐{4‐[2‐(4‐fluoro‐phenyl)‐ethyl]‐piperazine‐1‐carbonyl}‐1H‐indole‐3‐carbonitrile HCl (EMD 281014) in congenital learned helpless male rats in the forced swim test. The administration of EMD‐281014 (0.3–30 mg/kg i.p.) to congenital learned helpless rats dose‐dependently and significantly (at 10 and 30 mg/kg) decreased immobility and increased swimming compared to vehicle‐treated animals. Thus, EMD… 
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This review synthesizes the current literature about the behavioral, electrophysiological and neurochemical effects of 5-HT2 receptors ligands on the monoaminergic systems but also on adult hippocampal neurogenesis to shed some light on the preclinical evidence supporting the use of 5 -HT2A and/or 5- HT2C receptor antagonists such as antipsychotics, as potential effective adjuncts in SSRIs-resistant depression.
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