The highly selective 5‐hydroxytryptamine (5‐HT)2A receptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test

@article{Patel2004TheHS,
  title={The highly selective 5‐hydroxytryptamine (5‐HT)2A receptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test},
  author={Jignesh G Patel and Gerd D. Bartoszyk and E Edwards and Charles R. Ashby},
  journal={Synapse},
  year={2004},
  volume={52}
}
We examined the effect of the highly selective 5‐hydroxytryptamine (5‐HT)2A receptor antagonist 7‐{4‐[2‐(4‐fluoro‐phenyl)‐ethyl]‐piperazine‐1‐carbonyl}‐1H‐indole‐3‐carbonitrile HCl (EMD 281014) in congenital learned helpless male rats in the forced swim test. The administration of EMD‐281014 (0.3–30 mg/kg i.p.) to congenital learned helpless rats dose‐dependently and significantly (at 10 and 30 mg/kg) decreased immobility and increased swimming compared to vehicle‐treated animals. Thus, EMD… 
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A novel 5-HT2A receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: Approaching early-onset antidepressants
TLDR
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Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys
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These experiments, conducted in a non-human primate model, suggest that selective 5HT2A antagonists such as EMD 281014 could offer therapeutic benefit to younger and older psychiatric patients by improving working memory function.
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The blockade of the 5-HT2AR may strengthen the antidepressant-like effect of escitalopram by facilitating the enhancement of the brain NE transmission and provide support for the use of atypical antipsychotics with SSRIs as a relevant antidepressant augmentation strategy.
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TLDR
5- HT(2A) receptor antagonist and 5-HT(2C) receptor agonists exhibited effects similar to antidepressant drugs and abolished the depression-like effects in nicotine-withdrawn rats, and should be considered as adjuncts to smoking cessation therapy, to ameliorate abstinence-induced depressive symptoms.
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TLDR
The present data suggest S-MEPH may be a possible structural and pharmacological template to develop maintenance therapy for acute anxiety and depression during early withdrawal from psychostimulant abuse.
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TLDR
A physiological model of performance in the rat FST has been proposed involving the regulation of 5-HT transmission by corticotropin releasing factor (CRF), which is based on extensive evaluation of agonists and antagonists of individual 5- HT receptor subtypes.
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TLDR
The involvement of neuroplasticity pathways and/or the 5‐hydroxytryptaminergic system in the antidepressant‐like effect of this combined treatment, given subchronically is studied.
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Introduction: One third of depressed patients do not respond adequately to conventional antidepressants including the selective serotonin reuptake inhibitors (SSRIs). Therefore, multi-target drugs or…
Antidepressant Effect of Cnestis ferruginea Vahl ex DC (Connaraceae): Involvement of Cholinergic, Monoaminergic and L-arginine-nitric Oxide Pathways.
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C. ferruginea exerts its antidepressant-like action through interaction with α-adrenoceptor, dopamine D2,5-HT2B, 5-HT6 and muscarinic cholinergi1c receptors as well as L-arginine-nitric oxide systems and could be used as adjuvant with conventional antidepressants in the treatment of major depressive disorder.
5-HT2 ligands in the treatment of anxiety and depression
TLDR
This review synthesizes the current literature about the behavioral, electrophysiological and neurochemical effects of 5-HT2 receptors ligands on the monoaminergic systems but also on adult hippocampal neurogenesis to shed some light on the preclinical evidence supporting the use of 5 -HT2A and/or 5- HT2C receptor antagonists such as antipsychotics, as potential effective adjuncts in SSRIs-resistant depression.
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