The highly reducing sugar 2-deoxy-D-ribose induces apoptosis in human fibroblasts by reduced glutathione depletion and cytoskeletal disruption.

@article{Kletsas1998TheHR,
  title={The highly reducing sugar 2-deoxy-D-ribose induces apoptosis in human fibroblasts by reduced glutathione depletion and cytoskeletal disruption.},
  author={Dimitris Kletsas and Daniela Barbieri and Dimitri Stathakos and Berenice Botti and Stefania Bergamini and Aldo Tomasi and Daniela Monti and Walter Malorni and Claudio Franceschi},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={243 2},
  pages={416-25}
}
2-deoxy-D-Ribose (dRib), the most reducing sugar, induces apoptosis in normal human fibroblasts, as judged by cytoplasmic shrinkage, chromatin condensation, DNA fragmentation and mitochondrial depolarization. This effect is independent from culture conditions, such as cell density and the presence or absence of serum in the culture milieu, suggesting that dRib-induced apoptosis is cell cycle-independent. dRib was found also to provoke disruption of the actin filament network and detachment from… CONTINUE READING
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