The highly conserved and multifunctional NuA4 HAT complex.

@article{Doyon2004TheHC,
  title={The highly conserved and multifunctional NuA4 HAT complex.},
  author={Yannick Doyon and Jacques C{\^o}t{\'e}},
  journal={Current opinion in genetics & development},
  year={2004},
  volume={14 2},
  pages={
          147-54
        }
}
Histone acetyltransferase complexes have been shown to be key regulators of gene expression. Among these, the NuA4 complex, first characterized in yeast, stands out as it controls multiple key nuclear functions in eukaryotic cells. Many subunits of this protein assembly have been directly linked to global and targeted acetylation of histone H4 tails in vivo, regulation of transcription, cell-cycle progression as well as to the process of DNA repair. Recent studies presented here have… CONTINUE READING
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