The highly conserved N-terminal domains of histones H3 and H4 are required for normal cell cycle progression.

@article{Morgan1991TheHC,
  title={The highly conserved N-terminal domains of histones H3 and H4 are required for normal cell cycle progression.},
  author={Barry A. Morgan and Ben Mittman and M Mitchell Smith},
  journal={Molecular and cellular biology},
  year={1991},
  volume={11 8},
  pages={4111-20}
}
The N-terminal domains of the histones H3 and H4 are highly conserved throughout evolution. Mutant alleles deleted for these N-terminal domains were constructed in vitro and examined for function in vivo in Saccharomyces cerevisiae. Cells containing a single deletion allele of either histone H3 or histone H4 were viable. Deletion of the N-terminal domain of histone H4 caused cells to become sterile and temperature sensitive for growth. The normal cell cycle progression of these cells was also… CONTINUE READING