The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

@article{Rovati2007TheHC,
  title={The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.},
  author={Gianenrico Rovati and Val{\'e}rie Capra and Richard R. Neubig},
  journal={Molecular pharmacology},
  year={2007},
  volume={71 4},
  pages={
          959-64
        }
}
Despite extensive study of heptahelical G protein-coupled receptors (GPCRs), the precise mechanism of G protein activation is unknown. The role of one highly conserved stretch of residues, the amino acids glutamic acid/aspartic acid-arginine-tyrosine (i.e., the E/DRY motif), has received considerable attention with respect to regulating GPCR conformational states. In the consensus view, glutamic acid/aspartic acid maintains the receptor in its ground state, because mutations frequently induce… CONTINUE READING

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