The highest gene concentrations in the human genome are in telomeric bands of metaphase chromosomes.

@article{Saccone1992TheHG,
  title={The highest gene concentrations in the human genome are in telomeric bands of metaphase chromosomes.},
  author={Salvatore Saccone and Albertina De Sario and Giuliano Della Valle and Giorgio Bernardi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 11},
  pages={4913-7}
}
Chromosome in situ suppression hybridization has been carried out on human metaphase chromosomes to localize the G+C-richest human DNA fraction (which only represents 3.5% of the genome), as isolated by preparative equilibrium centrifugation in Cs2SO4/3,6-bis(acetatomercurimethyl)-1,4-dioxane density gradient. This fraction essentially corresponds to isochore family H3. The rationale for carrying out this experiment is that this isochore family has, by far, the highest gene concentration, the… CONTINUE READING
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