The higher toxicity of cereulide relative to valinomycin is due to its higher affinity for potassium at physiological plasma concentration.

@article{Teplova2006TheHT,
  title={The higher toxicity of cereulide relative to valinomycin is due to its higher affinity for potassium at physiological plasma concentration.},
  author={Vera V. Teplova and Raimo Mikkola and Anton A Tonshin and Nils-Erik Leo Saris and Mirja S. Salkinoja-Salonen},
  journal={Toxicology and applied pharmacology},
  year={2006},
  volume={210 1-2},
  pages={39-46}
}
Valinomycin and cereulide are bacterial toxins with closely similar chemical structure and properties but different toxic effects. Emetic poisoning is induced by cereulide but not by valinomycin. Both are specific potassium ionophores. Such compounds may affect mitochondrial functions. Both compounds cause a potassium-dependent drop in the transmembrane inner membrane potential due to the uptake of K+ as positively charged ionophore complex. Valinomycin is more potent than cereulide at high [K… CONTINUE READING
27 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…