The high-throughput yeast deletion fitness data and the theories of dominance.

@article{Manna2012TheHY,
  title={The high-throughput yeast deletion fitness data and the theories of dominance.},
  author={Federico La Manna and Romain Gallet and Guillaume Martin and Thomas Lenormand},
  journal={Journal of evolutionary biology},
  year={2012},
  volume={25 5},
  pages={892-903}
}
The development of high-throughput fitness measurement methods provides unprecedented power to test evolutionary theories. However, with this comes new challenges regarding data quality and data analysis. We illustrate this by reanalysing the fitness distribution in several environments of yeast mutants (homo- and heterozygous) from the yeast deletion project. Originally created to study functional properties of genes, evolutionary biologists took advantage of this database to study… CONTINUE READING