The high rate of familial lichen sclerosus suggests a genetic contribution: an observational cohort study

@article{Sherman2010TheHR,
  title={The high rate of familial lichen sclerosus suggests a genetic contribution: an observational cohort study},
  author={V Sherman and T McPherson and M Baldo and Alena Salim and X-H Gao and Fenella T. Wojnarowska},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2010},
  volume={24}
}
Background  Familial lichen sclerosus (LS) has been described in only 37 families. We feel that the association is under‐reported. 
New insights into potential risk factors and associations in genital lichen sclerosus: Data from a multicentre Italian study on 729 consecutive cases
TLDR
Data is not available on gender differences in genital lichen sclerosus (GLS), but information is available on risk factors associated with lichens sclerOSus and no data are available ongender differences. Expand
FAMILIAL LICHEN SCLEROSUS
TLDR
The clinical case — girl with lichen sklerosus has a familial, presence of similar disease in mother, girl's elder sister and widespread characteristics with lesion in anogenital region, back and extrimities. Expand
Oral lichen sclerosus: a systematic review of reported cases and two new cases
TLDR
The features of published oral lichen sclerosus (OLS) and two new cases are summarized to summarize the features of the chronic inflammatory mucocutaneous disease with uncertain etiology. Expand
Pediatric Lichen Sclerosus: A Review of the Epidemiology and Treatment Options
TLDR
New developments available in the current literature on the epidemiology and management of LS for children for children are reviewed. Expand
Frontal fibrosing alopecia and genital Lichen sclerosus: Single‐center experience
Despite the incidence of Frontal fibrosing alopecia (FFA) has been increasing in last two decades, the pathophysiology and trigger factors of FFA have not been yet fully understood.
Genital Vulvar Lichen Sclerosus in Monozygotic Twin Women: A Case Report and Review of the Literature
TLDR
This is a report of the occurrence of lichen sclerosus et atrophicus in monozygotic twin women, suggesting that inheritance is of relevance in the etiology of this disease. Expand
Clinical parameters in male genital lichen sclerosus: a case series of 329 patients
TLDR
The dermatological aspects of male genital lichen sclerosus have not received much prominence in the literature and the pathogenesis has not been specifically studied although autoimmunity (as in women) and HPV infection have been mooted. Expand
Pediatric Lichen Sclerosus: A Review of the Literature and Management Recommendations.
TLDR
Evidence-based guidance for treatment in the pediatric population of lichen sclerosus in children is provided and it is shown that early recognition and prompt management of the disorder is crucial in preventing long-lasting complications. Expand
A Dutch Cohort Study Confirms Familial Occurrence of Anogenital Lichen Sclerosus
TLDR
Families with at least one family member with LS diagnosed by a physician may be at increased risk of developing genital carcinoma in LS lesions, because 8.6 % of patients with LS had family members with LS. Expand
Lichen Sclerosus in Monozygotic Twins: A Familial LS
TLDR
A 29 year old female referred with a 5 year history of steroid responsive vulval pruritus was referred with loss of architecture, sclerotic changes on the labia majora and burrowing of the clitoris, consistent with the diagnosis of lichen sclerosus. Expand
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This report documents the disease in two additional families and adds genetic data on their HLA characteristics and the relationship of these factors to a possible autoimmune mechanism for the disease is discussed. Expand
HLA markers in familial Lichen Sclerosus
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Lichen sclerosus has been identified with increased frequency in families, often associated with HLA markers, mainly DQ7, and there is an association of LS with autoimmune disorders, such as the presence of anti‐thyroid peroxidase autoantibodies (anti‐TPO), a hallmark of autoimmune thyroid diseases. Expand
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TLDR
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TLDR
The present case report is concerned with the clinical course of vulval lichen sclerosus in sisters, which had almost simultaneously developed, and was successfully treated with a cream containing thyme extract. Expand
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TLDR
A case of a young woman with CREST syndrome who has a documented family history of two sisters with lichen sclerosus et atrophicus who presented with vulvar pruritas in association with dyspareunia is described. Expand
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TLDR
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TLDR
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