The high producer variant of the Fc-receptor like-3 (<ce:italic>FCRL3</ce:italic>) gene is involved in protection against multiple sclerosis

@article{Matesanz2008TheHP,
  title={The high producer variant of the Fc-receptor like-3 (<ce:italic>FCRL3</ce:italic>) gene is involved in protection against multiple sclerosis},
  author={Fuencisla Matesanz and Oscar Fern{\'a}ndez and Roger L Milne and Mar{\'i}a Fedetz and Antonio Alcina},
  journal={Journal of Neuroimmunology},
  year={2008},
  volume={195},
  pages={146-150}
}
Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case-control study of three SNPs in FCRL3 gene in 645 MS patients and 786 controls, all Caucasians from the South of Spain. Genotype and allele frequencies of two SNPs (rs7528684/FCRL3_3 and rs7522061/N28D), which were in high linkage disequilibrium (r(2) = 0.87), differed between MS cases and controls. The… CONTINUE READING

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