The high-mobility group protein B1-Toll-like receptor 4 pathway contributes to the acute lung injury induced by bilateral nephrectomy.

@article{Doi2014TheHG,
  title={The high-mobility group protein B1-Toll-like receptor 4 pathway contributes to the acute lung injury induced by bilateral nephrectomy.},
  author={Kent Doi and Tomoko Ishizu and Maki Tsukamoto-Sumida and Takahiro Hiruma and Tetsushi Yamashita and Emi Ogasawara and Yoshifumi Hamasaki and Naoki Yahagi and Masaomi Nangaku and Eisei Noiri},
  journal={Kidney international},
  year={2014},
  volume={86 2},
  pages={316-26}
}
Acute lung injury and acute kidney injury are severe complications in critically ill patients and synergistically increase mortality in intensive care units. Organ cross-talk between the kidney and the lung has been implicated recently as amplifying injury in each organ. Here we sought to identify a possible mechanism of acute kidney injury-induced acute lung injury using a mouse bilateral nephrectomy model. Toll-like receptor 4 (TLR4)-mutant C3H/HeJ mice were more resistant to lung injury… CONTINUE READING

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