The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation.

@article{Zhao2011TheHM,
  title={The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation.},
  author={Lu Zhao and Yong-hua Hu and Jin-sheng Sun and Li Sun},
  journal={Developmental and comparative immunology},
  year={2011},
  volume={35 10},
  pages={1052-8}
}
High mobility group box 1 protein (HMGB1) is a chromatin-associated nonhistone protein that is involved in nucleosome formation and transcriptional regulation. In addition, HMGB1 is also known as an extracellular cytokine that triggers inflammation and immune responses. HMGB1-like sequences have been identified in a number of fish species, however, the function of piscine HMGB1 remains uninvestigated. In this study, we reported the identification and analysis of SoHMGB1, an HMGB1 homologue from… CONTINUE READING