The high mobility group box: the ultimate utility player of a cell.


High mobility group (HMG) box proteins are abundant and ubiquitous DNA binding proteins with a remarkable array of functions throughout the cell. The structure of the HMG box DNA binding domain and general mechanisms of DNA binding and bending have been known for more than a decade. However, new mechanisms that regulate HMG box protein intracellular… (More)
DOI: 10.1016/j.tibs.2012.09.003